A Pioneering Fertility Preservation Method for Young Cancer Patients and Women at Risk of Ovarian Failure
It is an advanced fertility preservation technique in which ovarian tissue is surgically removed, frozen, and later transplanted back to restore fertility and also hormonal function. It is particularly beneficial for young cancer patients undergoing chemotherapy or women at risk of premature ovarian failure.
Steps in Ovarian Tissue Cryopreservation & Transplantation
Patient Assessment & Consultation
- Comprehensive evaluation by a fertility specialist
- Assessment of ovarian reserve through AMH, FSH, and ultrasound
- Discussion of risks, benefits, and expected outcomes
- Coordination with an oncology team if needed
2. Ovarian Tissue Retrieval (Laparoscopic Procedure)
- Minimally invasive laparoscopy to remove a small part or the entire ovary
- Performed under general anesthesia
3. Tissue Processing & Cryopreservation
- Ovarian cortex (which contains follicles) is carefully dissected
- Tissue is cut into thin strips for better preservation
- Slow freezing is used to cryopreserve the tissue to -196 degree celesius
- Stored in liquid nitrogen at ultra-low temperatures
4. Storage & Long-Term Preservation
- Tissue remains frozen until the patient is ready for transplantation
5. Ovarian Tissue Transplantation (Reimplantation)
- When the patient wishes to restore fertility, the tissue is thawed
- Surgical transplantation of ovarian tissue into the pelvic cavity or subcutaneous site
- Revascularization occurs, restoring ovarian function
Who is a Candidate for Ovarian Tissue Cryopreservation?
Young cancer patients before chemotherapy or radiation
Women at high risk of premature ovarian insufficiency (e.g., genetic conditions, autoimmune diseases)
Women undergoing pelvic surgeries that may affect ovarian function
Cancer Patients who need urgent chemotherapy and no time to undergo egg freezing
